ea0014p274 | (1) | ECE2007
Montanelli Lucia
, Ferrarini Eleonora
, Dimida Antonio
, Rossi Mario
, Agretti Patrizia
, Giorgi Franco
, Corsini Giovanni Umberto
, Pinchera Aldo
, Vitti Paolo
, Maggio Roberto
, Tonacchera Massimo
The insecticide DDT has been shown to inhibit both the basal and the TSH stimulated accumulation of cAMP in CHO stably transfected with the TSHr (CHO-TSHr). Aim of this study was to evaluate whether the DDT has a similar effect on cells transfected with TSHr mutants displaying a high level of constitutive activity. In addition we investigate the effect of DDT on cells transfected with wtFSHr and wtLHr which share a high degree of amino-acid homology sequence with wtTSHr. In co...